Expression System
Our team together with IBET
GenIbet, together with IBET, have extensive experience of working with and developing different microbial and mammalian expression systems (see list below) starting from the gene of interest. Our cell culture and molecular biology groups have the knowledge to maximize cell line productivity and adapt cells to grow in defined media compatible with downstream processing requirements (see also Process Development).
IBET and GenIbet have a solid track record in:
- Establishing stable and high producer cell lines ready for successful transfer to large scale production;
- Bioprocess development, including continuous integrated bioprocessing
- Analytical methods implementation, development and qualification to support development wor and batch certification/release
- Product stability testing
We can work with you on the selection of the most suitable expression system to produce your product in terms of cost, product quality and process efficiency.
Our track record includes:
- Mammalian cell lines (ex..HEK293, Perc 6, CAP, A549, MRC-5, Vero, MDCK, CHO, BHK).
- Insect cell lines (ex. SF9, SF21, Te Fly, Hi5, etc.)
- Bacteria/yeast (ex. Escherichia coli, Pichia Pastoris, etc.)
- Viruses (ex. Adenovirus, AAV, Retro and lentivirus, baculovirus, Rhabdoviruses and virus like particles, etc.)
In addition, we have agreements and facilitated access to a range of proprietary cell lines from selected partners such as Cevec Pharmaceuticals and Expres2Ion Biotechnologies.
